PREDNOS Study 2013.

Trial name or title	Long‐term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of nephrotic syndrome: national multicentre randomised double blind trial
Methods	Parallel RCT
Participants	Children presenting with first episode of SSNS, over 1 year and less than 1 year
Interventions	Treatment group: children will receive daily prednisolone for 6 days at the onset of URTI at the onset of each URTI during 12 months Control group: children will continue their current treatment (with placebo to maintain double blind) at the onset of each URTI during 12 months
Outcomes	Time to first relapse. To determine whether an extended course of prednisolone reduces the relapse rate, reduces the proportion of children who develop frequently relapsing or steroid dependent disease, reduces the requirement for a second or third line agent, is associated with an increased incidence of steroid related adverse events including behavioural problems, is more effective than standard course therapy
Starting date
Contact information	nicholas.webb@cmft.nhs.uk
Notes

SSNS ‐ steroid‐sensitive nephrotic syndrome; URTI ‐ upper respiratory tract infection