| Methods |
Adequate randomisation: yes, sealed envelopes
Allocation concealment: yes
Blinding of intervention: no
Blinding of measurement: not stated
Losses to follow up: none |
| Participants |
Preterm infants < 33 weeks (median 28, range 25‐32), arterial line, mean arterial BP 29 to 40 mmHg, normal blood glucose, no volume or inotrope support within preceding 3 hours
Mean postnatal age = 31.8 hrs (range 5‐224)
Mean gestation: Group 1: 27.9 weeks; Group 2: 28.6
Mean birthweight: Group 1: 1134g; Group 2: 1238g |
| Interventions |
Intervention:
Group 1 (n = 13): albumin 20% 15 mls/kg
Group 2 (n = 11): dopamine 5 mcg/kg/min |
| Outcomes |
Stated primary outcome: mean arterial BP, left ventricular output, global cerebral blood flow
Other outcomes: mortality, peri/intraventricular haemorrhage, periventricular leucomalacia |
| Notes |
Clinical data for mortality obtained from author. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
