| Methods |
Adequate randomisation: yes, sealed envelopes.
Allocation concealment: yes.
Blinding of intervention: no.
Blinding of measurement: not stated.
Losses to follow‐up: none. |
| Participants |
Preterm infants < 33 weeks (median 28, range 25‐32), arterial line, mean arterial BP 29 to 40 mmHg, normal blood glucose, no volume or inotrope support within preceding 3 hours.
Mean postnatal age = 31.8 hrs (range 5‐224).
Mean gestation: Intervention: 27.9 weeks; Control: 28.7 weeks
Mean birthweight: Intervention: 1134g; Control: 1238g. |
| Interventions |
Intervention (n = 13): albumin 20% 15 ml/kg.
Control (n = 12): no treatment. |
| Outcomes |
Stated primary outcome: mean arterial BP, left ventricular output, global cerebral blood flow.
Other outcomes: mortality, P/IVH, periventricular leucomalacia not available according to treatment groups. |
| Notes |
Data from publication used. Clinical data for mortality obtained from author. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
