Table 1.

Genome-wide significant loci in bipolar disorder

Nearest Gene	Chr	Marker	Risk Allele	P-value	Odds Ratio	Cases (N)	Controls (N)	Study
Loci with initial genome-wide significant evidence (P<5 × 10−8) and at least one additional replication
TRANK1	3p22	rs9834970	C	2.4 × 10−11	1.18	6,658	7,155	Chen et al,22 2011
				4.8 × 10−8	1.12	9,747	14,278	Muhleisen et al,24 2014
ANK3	10q21	rs10994415	C	6.9 × 10−11	1.27	9,747	14,278	Muhleisen et al,24 2014
ODZ4	11q14	rs12576775	A	4.4 × 10−8	0.88	11,974	51,792	PGC-BD et al,20 2011
				6.2 × 10−9	0.88	13,192	54,705	Green et al,23 2013
				4.5 × 10−9	0.85	9,747	14,278	Muhleisen et al,24 2014
CACNA1C	12p13	rs4765913	A	1.5 × 10−8	1.14	11,974	51,792	PGC-BD et al,20 2011
				9.8 × 10−10	1.14	13,192	54,705	Green et al,23 2013
NCAN	19p13	rs1064395	A	2.1 × 10−9	1.17	7,759	34,062	Cichon et al,21 2011
Loci with initial genome-wide significant evidence (P < 5 × 10−8)
RHEBL1/DHH	12q13	rs7296288	A	9.0 × 10−9	0.90	13,192	54,705	Green et al,23 2013
TRPC4AP	20q11	rs3818253	A	3.9 × 10−8	1.16	8,699	12,163	Green et al,23 2013
ADCY2	5p15	rs17826816	G	9.9 × 10−9	1.14	9,747	14,278	Muhleisen et al,24 2014
MIR2113; POU3F2	6q16	rs12202969	A	1.1 × 10−8	1.12	9,747	14,278	Muhleisen et al,24 2014
PTGFR	1p31	rs4650608	T	8.4 × 10−9	0.88	7,773	9,883	Chen et al,22 2011
LMAN2L	2q11	rs2271893	G	5.2 × 10−9	0.86	7,773	9,883	Chen et al,22 2011
Many genes	3p21	rs7618915	G	1.6 × 10−9	0.87	7,773	9,883	Chen et al,22 2011
SYNE1	6q25	rs9371601	T	2.9 × 10−8	1.10	9,368	10.929	Green et al,74 2013

Loci with subsequent evidence for replication in an independent sample are shown in the top part of the table, while loci with initial evidence for genome-wide significance only are shown in the bottom of the table. Although studies are listed independently, there is substantial overlap among the cases and controls between the studies.

Data from Refs.^20–24,74