Figure 1.

Schematic outline of the experimental protocols. The order of the 4 protocols was randomly assigned. In the overnight 10-minute blood sampling study, subjects received 1 mg ganirelix SC. LH pulses were given at 2-hour intervals, where 18.75 IU was infused over 6 minutes. A submaximal dose of GnRH (100 ng/kg) was administered IV at 1100 hours. In the other 3 arms, blood sampling was carried out every 10 minutes between 0800 and 1300 hours. The first dose of KTCZ was 800 mg, and the second dose 400 mg, together with 0.75 mg dexamethasone. A submaximal dose of ganirelix (0.125 mg/m² body surface) was administered at 2000 hours. Both LH and Te were measured in all samples.