Table 1.
Serum LH Concentrations and Secretion Parameters in 40 Healthy Men Sampled During 3 Hours at 10-Minute Intervals
| Serum concentrations | Control | Ganirelix | Ketoconazole | ANOVA |
|---|---|---|---|---|
| Mean 3-h LH (IU/L) | 3.99 ± 0.33 | 1.95 ± 0.19 | 6.42 ± 0.42 | <0.0001* |
| Median 3-h LH (IU/L) | 3.79 ± 0.32 | 1.81 ± 0.19 | 6.36 ± 0.42 | <0.0001* |
| Maximum LH (IU/L) | 6.02 ± 0.55 | 3.14 ± 0.30 | 8.32 ± 0.57 | <0.0001* |
| Minimum LH (IU/L) | 2.70 ± 0.25 | 1.26 ± 0.13 | 4.88 ± 0.31 | <0.0001* |
| Deconvolution | ||||
| Pulse frequency (#/3h) | 2.0 ± 0.1 | 1.8 ± 0.1 | 2.7 ± 0.2a | <0.0001 |
| Slow half-life (min) | 53 ± 4.0 | 63 ± 4.4 | 47 ± 2.3 | 0.007b |
| Mode (min) | 13.3 ± 1.1 | 14.1 ± 0.7 | 14.3 ± 0.8 | 0.47 |
| Basal secretion (IU/L/3h) | 15.7 ± 1.7 | 7.4 ± 1.0 | 26.0 ± 2.2 | <0.0001c |
| Pulsatile secretion (IU/L/3h) | 10.7 ± 1.3 | 5.1 ± 0.6 | 18.2 ± 2.3 | <0.0001c |
| Total secretion (IU/L/3h) | 26.4 ± 2.9 | 12.5 ± 1.4 | 44.3 ± 3.1 | <0.0001c |
| Mean pulse mass (IU/L) | 5.6 ± 0.5 | 3.0 ± 0.3 | 6.7 ± 0.7 | <0.0001c |
Data are shown as mean and SEM. The General Linear Model was used for the ANOVA of Repeat Measurements. Contrasts were evaluated with the Bonferroni correction.
Abbreviations: LH, luteinizing hormone.
Serum concentrations *Post hoc contrasts: Control vs Ganirelix and Ketoconazole: P < 0.0001, Ganirelix vs Ketoconazole: P < 0.0001. Deconvolution analysis: Contrasts were corrected with the Bonferroni procedure. aControl vs Ketoconazole P = 0.005, Ketoconazole vs Ganirelix P < 0.0001; bKetoconazole vs Ganirelix P = 0.007; cControl vs Ketoconazole and Ganirelix, and Ketoconazole vs Ganirelix P < 0.0001.