Table 2. Top 25 upregulated genes in P7 Tgfbr2;ScxCre mutant cells compared with P7 wild-type tenocytes (≥2 fold change, adjusted p<0.05).
See also Supplementary file 2 for a complete list of the downregulated genes.
| Gene symbol | Gene name | Fold change |
|---|---|---|
| Dlk1 | Delta-like one homolog (Drosophila) | 137.9 |
| Serpine2 | Serine (or cysteine) peptidase inhibitor, clade E, member 2 | 118.2 |
| Dpt | Dermatopontin | 95.7 |
| Ly6a | Lymphocyte antigen six complex, locus A | 54.3 |
| H19 | H19 | 51.1 |
| Cd34 | CD34 antigen | 47.8 |
| Lum | Lumican | 36.6 |
| Lgmn | Legumain | 31.8 |
| Cxcl12 | Chemokine (C-X-C motif) ligand 12 | 26.1 |
| Mfap5 | Microfibrillar associated protein 5 | 22.5 |
| Ly6c1 | Lymphocyte antigen six complex, locus C1 | 21.7 |
| Igf2 | Insulin-like growth factor 2 | 21.4 |
| Serping1 | Serine (or cysteine) peptidase inhibitor, clade G, member 1 | 19.2 |
| Mgst1 | Microsomal glutathione S-transferase 1 | 18.3 |
| Aspn | Asporin | 15.9 |
| Mt1 | Metallothionein 1 | 15.4 |
| Mgst3 | Microsomal glutathione S-transferase 3 | 13.1 |
| Col3a1δ | Collagen, type III, alpha 1 | 13.0 |
| Postn | Periostin, osteoblast specific factor | 13.0 |
| Itm2a | Integral membrane protein 2A | 12.7 |
| Ptn | Pleiotrophin | 10.3 |
| Rps18-ps3 | Ribosomal protein S18, pseudogene 3 | 9.7 |
| Gsn | Gelsolin | 8.3 |
| Ifitm3 | Interferon induced transmembrane protein 3 | 8.2 |
| Col5a1δ | Collagen, type V, alpha 1 | 8.1 |
Note: δ = genes related to tendons.