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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Nat Metab. 2019 Dec 23;2(1):97–109. doi: 10.1038/s42255-019-0152-6

Figure 6. Progenitor clusters specific to VAT derived from individuals with obesity.

Figure 6

(a) Re-clustering of VAT-specific progenitors (9,847 cells) from the complete sample set (b) Violin plots showing expression density of MSLN and CFD in 6 VP clusters. The y axis indicate log transformed expression values and the width indicate number of cells expressing the particular gene (c) VAT progenitor cells labelled based on mitochondrial gene distribution: group 0 (grey, 5,018 cells) shows cells with mitochondrial gene expression <=5%, group 1 (blue, 4,100 cells) represents 6% to 14% and group 2 (red, 729 cells) represents 15% to 24% expression. See also supplementary figure 5 (d) Pearson correlation of fasting glucose levels (mmol/L) and VPM cell proportion across all samples from 12 individuals (e) Expression pattern of UCP1, MSLN wnd WT1 using bulk RNASeq showing change in expression in mature adipocytes.