Figure 1: A generic and unifying HIV prevention cascade framework. A: The core steps of the cascade of motivation to use the prevention method, access to it, and effective use of it in a priority population that would benefit from use of the prevention method. B: The complete cascade that shows the gaps in the cascade across motivation, access, and effective use, and major reasons underlying these gaps. The displayed reasons do not represent an exhaustive list and, although some of these reasons are likely to be widely applicable, they may differ in relative importance between settings, populations, and prevention methods. The reasons provide links to interventions and platforms for interventions to improve motivation, access, and effective use in the priority population.