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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Nature. 2020 Feb 5;578(7794):290–295. doi: 10.1038/s41586-020-1979-4

Extended Data Figure 8. Relationship of PlxnD1 with other established mechanosensors.

Extended Data Figure 8

(a) PECAM+/+ and PECAM-/- ECs were incubated with anti-PlxnD1-coated beads and subjected to force application for 5 minutes before examining phosphorylation of vinculin (n=3; *p < 0.05). (b,c) Mouse ECs were treated with siRNAs to Piezo1 and Gαq/11, then incubated with anti-PlxnD1-coated beads and subjected to force application for 5 minutes before examining phosphorylation of vinculin (n=3; *p < 0.05). The data represent mean±SEM. P-values were obtained by performing two-tailed Student's t test using Graphpad Prism