Figure 11.

The Mbd2-KO Mice Attenuated I/R-Induced RGC Apoptosis via the lncRNA Mbd2-AL1/miR-188-3P/Traf3 Axis

The IOP of homozygous mice deficient in Mbd2 and wild-type littermates was elevated to 120 mmHg for 1 h, and the retinas were dissected 24 h later. (A and B) Quantitative real-time PCR analysis of the levels of lncRNA Mbd2-AL1 and miR-188-3p in retinas of four groups. (C and D) Western blot with statistical analysis showing the levels of Traf3, cleaved caspase3, and Mbd2 in 4 different groups. The data were expressed as mean ± SEM of five independent experiments. #p < 0.05 versus Mbd2-WT/sham group; *p < 0.05 versus Mbd2-WT/I/R group.