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Schematic Diagram Summarizing the Role of Mbd2 in I/R-Induced RGC Apoptosis
In retinal I/R, Mbd2 promotes the transcription of Mbd2-AL1 via the hypomethylation of its promoter, which serves as a sponge that prevents miR-188-3p from mediating the downregulation of Traf3, which eventually leads to RGC apoptosis.
