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. 2020 Feb 11;10:38. doi: 10.3389/fcimb.2020.00038

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Copyright © 2020 Su, Sravanam, Gorantla, Kaminski, Khalili, Poluektova, Gendelman and Dash.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Recipient humanized mice engrafted from donor humanized mice under effective treatment. A total of 5 naïve humanized mice received adoptive transfer among which three (M344, M467, and M473) received splenocytes engraftment, and two (M329 and M358) received PBMCs engraftment. (A) Peripheral VL of individual spleen and PBMCs recipients after adoptive transfer, respectively. (B) Peripheral CD4+ T cell levels of individual spleen and PBMCs recipients after adoptive transfer. (C,E) tissue HIV-1 DNA and (D,F) tissue HIV-1 RNA in individual donor humanized mice was evaluated across spleen, gut, lung, brain, liver, and kidney, using semi-nested real time qPCR. M344 (red) received spleen transfer from donor M352. M473 and M358 (blue) received spleen and PBMCs engraftment from M375, respectively. M467 and M329 (green) received spleen and PBMCs engraftment from M387, respectively. The dotted line in (A) indicates the detection limit (DL) of 400 HIV-1 RNA copies/ml. The dotted line in (C–F) showed the DL below 10 HIV-1 copies/10⁶ human CD45+ cells.