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. 2020 Feb 11;10:1685. doi: 10.3389/fphar.2019.01685

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Copyright © 2020 Yang, Xiang, Xiang, He, Liu, Lan, Li, Jiang, Ren, Liu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hepatoprotective effects of baicalin against EE-induced hepatotoxicity. (A) The chemical structure of baicalin. (B) Serum aminotransferase (ALT), aspartate aminotransferase (AST), and AKP. (C) H&E stained liver sections showing the hepatic structure changes. Areas of inflammatory cells infiltration are indicated by arrows. (D) TEM images showing substructural changes of hepatocytes. (D) The bile flow rate in rats over 2 hours. Data are presented as the mean ± SD. (n = 6). **p < 0.01 versus the control group, ^#p < 0.05 and ^##p < 0.01 versus the EE group.