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. 2020 Feb 11;10:1685. doi: 10.3389/fphar.2019.01685

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Copyright © 2020 Yang, Xiang, Xiang, He, Liu, Lan, Li, Jiang, Ren, Liu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalin promotes bile acid (BA) efflux and reduces BA influx in cholestatic rats. (A) The mRNA expression of BA uptake transporters, Ntcp, Oatp1a1, and Oatp1b2. (B) The protein level of NTCP. (C) The mRNA expression of BA efflux transporters, Bsep, Mrp2, Mrp3, Mrp4, and Mdr2. (D) The protein level of BSEP and MRP2. (E) Immunohistochemically staining for NTCP, BSEP, and MRP2 in rat liver. Data are presented as the mean ± SD (n = 6). *p < 0.05 and **p < 0.01 versus the control group, ^#p < 0.05 and ^##p < 0.01 versus the EE group.