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. 2020 Feb 11;7:396. doi: 10.3389/fcell.2019.00396

FIGURE 1.

FIGURE 1

Sevoflurane increases the levels of CypD, but not ANT or VDAC, in hippocampus tissues of WT young mice. (A) Western blot shows that sevoflurane anesthesia (lanes 4–6) increases the levels of CypD, but not ANT or VDAC, other two components of mPTP, as compared to the control condition (lanes 1–3) in the hippocampus tissues of WT mice. There is no significant difference in the amounts of β-actin in the hippocampus tissues between the mice in the control condition group and the mice in the sevoflurane anesthesia group. (B) Quantification of the Western blot shows that the sevoflurane anesthesia (black bar) increases CypD levels as compared to the control condition (white bar). (**P = 0.024, Student’s t test with post hoc Bonferroni adjustment, N = 6). (C) Sevoflurane anesthesia (row b) increases the levels of CypD compared to the control condition (row a) in the hippocampus tissues of WT mice. Column 1 is the CypD (red) staining, and column 2 is CypD merged with the DAPI (blue) nuclear staining. (D) Quantification of the image shows that sevoflurane anesthesia (black bar) increases CypD levels as compared to the control condition (white bar). (**P = 0.010, Student’s t test, N = 6).