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. 2020 Feb 11;7:396. doi: 10.3389/fcell.2019.00396

FIGURE 4.

FIGURE 4

Sevoflurane induces a CypD-dependent cognitive impairment in young mice. (A) Two-way ANOVA with repeated measurement analysis shows that there is significant interaction between the treatment (control condition and sevoflurane anesthesia) and time (P28 to P34) on escape latency (N = 10 in each group, F = 2.970, *P = 0.012) in the WT mice. The post hoc (Bonferroni) test shows that the mice following the sevoflurane anesthesia have longer escape latency than the mice following the control condition at P32, P33, and P34. (B) The Mann–Whitney test shows that the WT mice following the sevoflurane anesthesia have less platform crossing times than the WT mice following the control condition (N = 10 in each group, P = 0.011). (C) Two-way ANOVA with repeated measurement analysis shows that there is no significant interaction between the treatment (control condition and sevoflurane anesthesia) and time (P28 to P34) on escape latency (N = 10 in each group, F = 1.825, P = 0.098) in the CypD KO mice. (D) The Mann–Whitney test shows that there is no significant difference in platform crossing times between the CypD KO mice following the sevoflurane anesthesia and the CypD KO mice following the control condition (N = 10 in each group, P = 0.936). N.S., not significant.