Table 1.

The post hoc comparison of repeated ketamine vs. single ketamine in rats bred for negative (NC) cognitive state for local graph analytical metrics (increase ↑ or decrease ↓). Triangle (∇) signifies values surviving FDR correction (q < 0.05). See legends of Figs. 3 and 4 for the abbreviations of brain regions.

Brain regions	p Value
	Degree	Strength	Betweenness centrality	Clustering coefficient	Local efficiency
Amyg			↓ 0.0230
Au		↑ 0.0169	↑ 0.0016∇		↑ 0.0001∇
BNST		↑ 0.0060∇	↑ 0.0384		↑ 0.0244
Cg1	↓ 0.0046∇				↓ 0.0097
Cg2	↓ 0.0031∇
DLT	↑ 0.0086∇	↑ 0.0005∇	↑ 0.0005∇	↑ 0.0307	↑ 0.0134
DRN	↓ 0.0107∇
HcPD	↓ 0.0028∇	↓ 0.0390	↓ 0.0375
HcV	↓ 0.0349
I	↑ 0.0307	↑ 0.0056∇			↑ 0.0237
IL				↓ 0.0003∇	↓ 0.0140
M1	↑ 0.0130∇	↑ 0.0012∇
M2	↑ 0.0200
OF				↓ 0.0039∇	↓ 0.0086∇
PtA		↑ 0.0191			↑ 0.0040∇
S2	↑ 0.0016∇	↑ 0.0002∇	↑ 0.0001∇
SC	↑ 0.0047∇	↑ 0.0066∇			↑ 0.0318
Sept			↓ 0.0333	↓ 0.0206	↓ 0.0008∇
SN		↑ 0.0136
TeA	↓ 0.0011∇
VTA					↑ 0.0159
ZI	↑ 0.0377∇	↑ 0.0035∇	↑ 0.0445