Fig. 2. Reduced vertical activity and motor learning deficit in Ube3a^m−/p+ rats.

a At PND 19, Ube3a^m−/p+ juvenile rats exhibited normal horizontal activity but b had significantly reduced vertical activity compared to wildtypes. c Center time did not differ between groups. d At PND 40, Ube3a^m−/p+ rats again exhibited normal horizontal activity, e significantly lower vertical activity, and f normal center time. Note: the difference in axis labels shows how much more active PND 40 rats are over PND 19. g In the adhesive removal task, Ube3a^m−/p+ rats had significantly higher latencies to initiate removal of the adhesive. h Latency to completely remove the adhesive did not differ between groups but trended longer (p = 0.059) in the Ube3a^m−/p+ rats, suggesting fine motor skill deficits of the fore paws. i Ube3a^m−/p+ rats had significantly lower latencies to fall of the rotarod on day 3 compared to wildtypes. Analyses include both males and females. Mean +/− S.E.M. is depicted. a–f: *p < 0.05, repeated measures ANOVA, main effect of genotype. g–h: *p < 0.05, Student’s t-test. i: *p < 0.05, repeated measures ANOVA, Holm-Sidak’s multiple comparisons test.