Fig. 4. Neuroanatomical pathology in Ube3a^m−/p+ rats at PND 21.

Representative coronal slice series highlighting regional brain differences in absolute (mm³) and relative (%) brain volume between Ube3a^m−/p+ and Ube3a^m+/p+ (left) and between Ube3a^m+/p− and Ube3a^m+/p+ (right). Regions with decreased volume in Ube3a^m−/p+ include the cerebral cortex, cerebellum, and amygdala. Regions with increased volume in Ube3a^m−/p+ include the periacqueductal gray, thalamus, and hypothalamus. Ube3a^m+/p− did not exhibit altered neuroanatomy compared to wildtype. Analyses include both males and females.