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. 2020 Feb 17;10:2757. doi: 10.1038/s41598-020-59671-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between HRD status and DNA promoter methylation of HRR-related genes. (A) BRCA1 methylation. Left: HRD cases; Center: non-HRD cases. X-axis: Average values of two BRCA1 mRNA expression probes normalized to 0–1. Y-axis: β value of cg04658354. Right: Distribution of BRCA1 methylated cases. (B) RAD51C methylation. X-axis: Average values of two RAD51C mRNA expression probes normalized to 0–1. Y-axis: β value of cg14837411. RAD51C methylation cases are surrounded by a blue line in the upper-left region. The frequency of RAD51C methylation differs greatly between HRD cases (left) and non-HRD cases (right).