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. 2020 Feb 5;10:35. doi: 10.1038/s41398-020-0723-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Open-field test (WT, n = 13; Del(3.0 Mb)/ + , n = 9). a The total distance moved during the 10-min test period. b The number of transitions between the outer and inner zones. c Percentage of time spent in the outer zone. d Percentage of auditory prepulse inhibition (PPI) (WT, n = 15; Del(3.0 Mb)/ + , n = 15). Auditory PPI was measured at four different prepulse levels (69, 73, 77, and 81 dB). e Measurements of acoustic startle responses to the 120-dB startle stimulus. f Measurements of visual PPI (WT, n = 13; Del(3.0 Mb)/ + , n = 9). Visual PPI was measured at two conditions of light prepulse duration (20 or 25 ms). g Five-trial direct social interaction test (WT, n = 13; Del(3.0 Mb)/ + , n = 9). A subject mouse was habituated to the same intruder of juvenile mouse (trials 1–4) and dishabituated toward a novel mouse (trial 5). Time length spent interacting with the intruder was evaluated. Each 5-min trial was separated by a 30-min interval. h Fear-conditioning test. A context-dependent freezing response (%) is shown on the left panel towards the tone and foot–shock paring (conditioning) measured 24 h after the initial exposure. A cue-dependent freezing response (%) is shown on the right panel measured 48 h after the conditioning. Two-tailed Welch’s t tests (a, b, c, e, fifth trial of g and h) or two-way repeated-measures ANOVA (d, f, 1–4 trial of g). All data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.