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. 2020 Feb 5;10:35. doi: 10.1038/s41398-020-0723-z

Fig. 3. Performance of WT and Del(3.0 Mb)/ + mice in visual discrimination (VD) and reversal learning.

Fig. 3

a Experimental schedule for visual discrimination and reversal learning tasks. b A total number of trials to reach the criterion in the pre-training task. c A total number of trials to reach the criterion in VD task. d Acquisition of the first four sessions in VD learning. e Percentage of correct responses and f perseveration index on the early, middle, and late stages of reversal learning. R early, first reversal learning session. R middle, session midway through reversal session. R late, final reversal session. All data are expressed as means ± SEM (WT, n = 7; Del(3.0 Mb)/ + , n = 6). *p < 0.05, **p < 0.01. g–j Basal synaptic transmission in the mPFC of Del(3.0 Mb)/ + mice. Layer 2/3 pyramidal neurons in acute mPFC slices from 2-week-old Del(3.0 Mb)/ + and WT littermates were whole-cell patch clamped and miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs) were recorded. Bar graphs show the amplitude (g, i) and the frequency (h, j) of mEPSC (g, i) and mIPSC (h, j), respectively. Data are expressed as mean ± SEM (n = 19–20 cells from WT control mice and n = 20 cells from Del(3.0 Mb)/ + mice).