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. 2020 Feb 13;14:603–611. doi: 10.2147/DDDT.S224308

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© 2020 Liu et al.

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Silibinin in combination with valsartan notably attenuated HFD-induced renal fibrosis of mice in vivo. (A) Body weight of mice was determined. (B) Kidney weight/body weight of HFD-induced mice was measured. (C) Microalbuminuria of mice from control, HFD, HFD+valsartan, HFD+silibinin or HFD+valsartan+silibinin groups was measured. (D) H&E staining of mice kidney tissue in control, HFD, HFD+valsartan, HFD+silibinin or HFD+valsartan+silibinin group was detected. (E) Masson staining of mice kidney tissue in control, HFD, HFD+valsartan, HFD+silibinin or HFD+valsartan+silibinin groups was detected. (F) The area of fibrosis in mice was quantified. **P<0.01 vs control group; ^#P<0.05 vs HFD group; ^##P<0.01 vs HFD group.