Fig. 5. Relationship between volume of the dorsolateral prefrontal cortex (in cm³) and inferior frontal gyrus (DLPFC/IFG) as measured with magnetic resonance imaging and AMPH-induced reductions in non-displaceable binding potential (BP_ND) values of the dopamine D_2/3 receptor positron emission tomography (PET) radioligand [¹¹C]-(+)-PHNO in healthy subjects before and after sensitization to d-amphetamine compared to patients with schizophrenia.

Significant interactions are found in brain regions (GP, SNVTA) where dopamine D₃ (in contrast to D₂) receptors are the predominant source of signal detected with [¹¹C]-(+)-PHNO and PET. VST, ventral striatum; GP, globus pallidus; SNVTA, substantia nigra/ventral tegmental area.