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. 2020 Feb 17;10:2717. doi: 10.1038/s41598-020-59624-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of co-delivery of Pt and DOX by PEGylated nano-graphene oxide for improving anticancer activity. (A) The synthesis of pGO-Pt/DOX dual-drug delivery system, which included the step of covalent functionalization by PEG forming pGO nanoparticle, followed by covalent functionalization by Pt and non-covalent functionalization by DOX. (B) Schematic illustration of tumor-targeted pGO-Pt/DOX nanoparticle to achieve superior anticancer efficacy by generating DNA lesions (Pt) and preventing the DNA replication (DOX).