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. 2020 Feb 17;10:2717. doi: 10.1038/s41598-020-59624-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of pGO-Pt/DOX nanoparticles. (A) TEM image of pGO-Pt/DOX. (B)UV-Vis spectra of pGO-Pt/DOX, pGO-Pt, Pt and DOX. (C) The drug loading efficiency (DLE) of pGO-Pt/DOX, the saturated DLE of Pt was at around 0.376 mg/mg. we managed to optimize the finally weight ratio of DOX: PT: pGO = 0.376: 0.376: 1. Thereby, the DLE of DOX reached to 0.376 mg/mg when the initial concentration was 0.658 mg/mL (the including-pGO concentration of 1.0 mg/mL). (D) The release profile of Pt and DOX from pGO-Pt/DOX in buffers at pH 5.3 and 7.4.