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. 2020 Feb 17;10:2717. doi: 10.1038/s41598-020-59624-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Quantification analysis of both Pt and DOX amounts in tumor after 12 h post-injection of pGO-Pt/DOX and Pt/DOX mixture, respectively. Bars, mean ± SD (n = 6). (B) Body weight curves after treatment with PBS, pGO, pGO-Pt/DOX, and Pt/DOX mixture, respectively. Bars, mean ± SD (n = 6). (C) H&E staining images of major organs (heart, liver, spleen, lung and kidney) after different treatments. Black arrows represent myocardial congestion and cardiomyocyte hypertrophy. Yellow arrows represent splenic nodule. Scale bar: 100 μm.