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. 2020 Jan 27;10:5. doi: 10.1038/s41387-020-0108-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Human EndoC-βH1 beta-cells (a) and isolated rat islets (b) were incubated for 2 days with compositions of different FFAs (total concentration 500 µM each) simulating the most popular edible plant oils. In addition EndoC-βH1 beta-cells were incubated with further FFA compositions mimicking additional edible oils and butter (c–e) as well as with mixtures composed of equal volumes of selected FFA compositions (f). Mixture 1a contained the FFA compositions mimicking coconut oil, olive oil, linseed oil, and palm oil while mixture 1b was composed of the FFA compositions mimicking palm kernel oil, soybean oil, sunflower oil, and safflower oil. Mixture 2a contained the FFA compositions mimicking rapeseed oil, sesame oil, peanut oil, and walnut oil whereas mixture 2b was made of the FFA compositions mimicking linseed oil, soybean oil, rapeseed oil, and walnut oil. After incubation activation of caspase-3 was measured. Data are expressed as means ± SEM of 4–9 independent experiments. **p < 0.01 compared to untreated cells (Dunnett’s Multiple Comparison Test).