Table 2.
Differentially methylated positions associated with ADHD and the ADHD PRS.
| Probe | Coefficient | P-value | Chrom | Position | Strand | Gene |
|---|---|---|---|---|---|---|
| (A) ADHD vs. control | ||||||
| cg17478313 | 0.009285 | 1.54E–06 | 14 | 23653041 | − | SLC7A8 |
| cg21609804 | 0.013772 | 2.82E–06 | 11 | 63678193 | + | MARK2 |
| cg03416665 | −0.00682 | 4.64E–06 | 4 | 95373403 | − | PDLIM5 |
| cg27034450 | 0.007208 | 4.82E–06 | 8 | 145649435 | − | VPS28 |
| cg02466711 | −0.00264 | 6.03E–06 | 8 | 102218365 | + | ZNF706 |
| cg00964221 | −0.00459 | 8.40E–06 | 8 | 30240029 | − | Intergenic |
| cg06972911 | −0.00646 | 9.50E–06 | 18 | 30051803 | + | FAM59A |
| (B) ADHD polygenic risk score | ||||||
| cg15472673 | −0.01258 | 6.71E–08 | 21 | 34915098 | − | GART, SON |
| cg05348870 | 0.022926 | 1.85E–06 | 19 | 6671045 | + | TNFSF14 |
| cg03391479 | 0.015117 | 1.88E–06 | 4 | 114901073 | + | ARSJ |
| cg03838680 | 0.012572 | 2.22E–06 | 3 | 46887195 | − | Intergenic |
| cg00428296 | 0.015183 | 2.96E–06 | 1 | 230513970 | − | PGBD5 |
| cg17233422 | 0.02449 | 3.89E–06 | 3 | 66467994 | + | LRIG1 |
| cg13011002 | 0.009106 | 4.48E–06 | 2 | 28837591 | − | PLB1 |
| cg04453792 | 0.025432 | 4.68E–06 | 16 | 23158863 | − | USP31 |
| cg12237140 | 0.012843 | 4.93E–06 | 19 | 47988486 | − | KPTN |
| cg16536664 | −0.01169 | 5.61E–06 | 3 | 186288091 | + | DNAJB11, TBCCD1 |
| cg11425280 | −0.01202 | 5.98E–06 | 12 | 104851172 | + | CHST11 |
| cg26223996 | 0.011179 | 7.34E–06 | 15 | 74906395 | − | CLK3 |
| cg25332391 | 0.012247 | 9.92E–06 | 5 | 31505476 | + | DROSHA |
| (C) ADHD-by-sex interactions | ||||||
| cg25779690 | −0.01095 | 1.10E–06 | 12 | 56385212 | − | RAB5B |
| cg08698885 | −0.00938 | 1.87E–06 | 2 | 96767035 | + | Intergenic |
| cg26975193 | −0.00619 | 2.62E–06 | 7 | 158824399 | − | VIPR2 |
| cg11411509 | −0.01062 | 3.02E–06 | 6 | 33157746 | + | COL11A2 |
| cg03537872 | −0.02137 | 3.72E–06 | 12 | 109459024 | + | SVOP |
| cg05457620 | −0.01166 | 4.21E–06 | 5 | 168310308 | + | SLIT3 |
| cg15718572 | −0.03317 | 5.34E–06 | 1 | 207818003 | + | CR1L |
| cg23824987 | 0.00986 | 8.91E–06 | 16 | 69497556 | − | CYB5B |
| cg18031661 | 0.01126 | 9.87E–06 | 5 | 163133751 | + | Intergenic |
| (D) ADHD PRS-by-sex interactions | ||||||
| cg20954180 | 0.03722 | 2.09E–06 | 3 | 54606265 | + | CACNA2D3 |
| cg06174989 | 0.07740 | 2.40E–06 | 16 | 90114523 | − | LOC100130015 |
| cg08911728 | −0.03989 | 2.89E–06 | 5 | 109189484 | + | MAN2A1 |
| cg22225943 | 0.07494 | 4.55E–06 | 11 | 2162536 | − | IGF2; INS-IGF2; IGF2AS |
| cg05407555 | −0.01942 | 9.23E–06 | 14 | 106320510 | − | Intergenic |
All differentially methylated probes with p-value ≤ 1e–5 for all models: (A) DMPs associated with ADHD diagnosis, (B) DMPs associated with ADHD polygenic risk (PRS), (C) DMPs showing a sex-by-ADHD interaction, and (D) DMPs showing a sex-by-PRS interaction