Figure 2.

High NOD1 expression is associated with decreased overall survival in patients with colorectal cancers. (A) Using OncoLnc, TCGA RNA-Seq COAD data is analyzed by correlating overall survival with NOD1 expression levels (High vs. Low). Having high levels of NOD1 is associated with poorer survival (Log rank P = 0.0457). The “High” and “Low” NOD1 expression represents non-overlapping top and bottom 25% NOD1-expressing tumors, respectively. (B) Using TMA of human CRC, overall survival data is analyzed by correlating them with changes in NOD1 protein expression levels (High vs. Low). There is no significant association between high levels of NOD1 and overall survival (P = 0.167) based on our current data. The “High” and “Low” NOD1 expression represents non-overlapping tumor cores with 2+ and 0+ change in NOD1 intensity compared to baseline, respectively