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. 2018 Oct 15;30(1):3–44. doi: 10.1007/s00198-018-4704-5

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© International Osteoporosis Foundation and National Osteoporosis Foundation 2018, corrected publication 2020

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 14 — Correlation between the 10-year probability of a major fracture (calculated with BMD) and cost-effectiveness of generic alendronate at the age of 50 years in women (BMI set to 26 kg/m²). Each point represents a particular combination of BMD and clinical risk factors (all possible combinations of CRFs at BMD T-scores between 0 and − 3.5 SD in 0.5 SD steps—512 combinations) with a BMI set to 26 kg/m². The horizontal line denotes the threshold for cost-effectiveness (a willingness to pay of £20,000/QALY gained). From [114], with kind permission from Springer Science and Business Media