Table 1.
Hemodynamics under anesthesia and plasma neurohumoral parameters in the remodeling study
| CST group (n = 13) | CDT group (n = 14) | P value | |
|---|---|---|---|
| BW, g | 428 ± 9 | 430 ± 7 | NS |
| HW, g/kg | 2.97 ± 0.05 | 2.77 ± 0.07 | < 0.05 |
| Infarct size, % | 47 ± 1 | 48 ± 1 | NS |
| MBP, mmHg | 88 ± 2 | 83 ± 2 | NS |
| HR, bpm | 304 ± 8 | 309 ± 5 | NS |
| CI, mL/min/kg | 145 ± 11 | 181 ± 13 | < 0.05 |
| LV + dp/dtmax, mmHg/s | 3116 ± 145 | 3699 ± 81 | < 0.01 |
| LV − dp/dtmax, mmHg/s | 2682 ± 119 | 3108 ± 118 | < 0.05 |
| LVEDP, mmHg | 28 ± 1 | 20 ± 2 | < 0.01 |
| RAP, mmHg | 8 ± 1 | 5 ± 1 | < 0.01 |
| Plasma (pg/mL) | |||
| Norepinephrine | 1566 ± 217 | 741 ± 215 | < 0.05 |
| Epinephrine | 2248 ± 445 | 893 ± 233 | < 0.05 |
| BNP | 429 ± 27 | 359 ± 8 | < 0.05 |
| AVP | 724 ± 49 | 490 ± 43 | < 0.01 |
| ANG II | 138 ± 33 | 60 ± 10 | < 0.05 |
Values are means ± SEM. NS not significant. Hemodynamic parameters assessed by unpaired Student’s t-test. Plasma neurohumoral parameters assessed using a non-parametric Mann–Whitney U-test
BW, body weight; HW, biventricular weight normalized by body weight; MBP, mean arterial pressure; HR, heart rate; CI, cardiac index (cardiac output/BW); LV + dp/dtmax, maximum positive dp/dt of left ventricular pressure; LV − dp/dtmax, maximum negative dp/dt of left ventricular pressure; LVEDP, left ventricular end-diastolic pressure; RAP, right atrial pressure. BNP, brain natriuretic peptide; AVP, arginine vasopressin; ANG II, angiotensin II