Table 3.

Univariate and multivariate survival analyses of SBBC patients.

Category		Univariate Cox analysis (DFS)		Multivariate Cox analysis (DFS)
		Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age at menarche	≤ 14 years vs. >14 years	1.696 (0.823–3.491)	0.152	–	–
Menopause status	Premenopausal vs. menopausal	1.282 (0.623–2.641)	0.5	–	–
Age	≤ 50 years vs. >50 years	0.832 (0.404–1.715)	0.619	0.887 (0.391–2.010)	0.774
Family history	Breast cancer vs. no history	0.556 (0.212–1.454)	0.231	–	–
pT	pTis/pT1 vs. pT2/3	1.966 (0.875–4.416)	0.102	1.027 (0.431–2.448)	0.952
BMI	<24 vs. ≥24	1.236 (0.588–2.600)	0.576	–	–
Number of pregnancies	≤ 2 times vs. >2 times	1.758 (0.823–3.757)	0.145	–	–
pN	LN-negative vs. LN-positive	0.291 (0.141–0.599)	0.001	0.361 (0.166–0.787)	0.01
Histopathology	Lobular component vs. no lobular component	0.730 (0.279–1.907)	0.521	0.746 (0.252–2.203)	0.595
Bilateral ER consistency	Bilateral concordant vs. bilateral discordant	0.951 (0.409–2.217)	0.907	–	–
ER status	Positive vs. negative	0.506 (0.207–1.240)	0.136	0.473 (0.167–1.338)	0.158
HER2 status	Positive vs. negative	0.614 (0.263–1.430)	0.258	0.531 (0.208–1.357)	0.186
BRCA1/2 status	Wild type vs. mutated	1.068 (0.409–2.790)	0.894	0.585 (0.431–2.448)	0.355
LVI	Positive vs. negative	0.664 (0.304–1.450)	0.304	–	–
ER status for 3y DFS	Positive vs. negative	0.324 (0.126–0.837)	0.020	0.179 (0.050–0.644)	0.008