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. 2020 Feb 11;11:20. doi: 10.3389/fimmu.2020.00020

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Copyright © 2020 Bonezi, Cataneo, Branquinho, Silva, Gonzalez-Dias, Pereira, Ferreira, Nakaya, Campa, Wowk and Silveira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Contrasting pattern of the tryptophan metabolism induced in PBMC cultures stimulated by a DENV4 clinical isolate (422) or flaviviruses that elicit low ASC responses in vivo (ZIKV MR766, ZIKV PE243, and attenuated Yellow Fever 17DD). Different PBMC cultures derived from healthy donors had cells and supernatants obtained at day 7 of the cultures. (A) ASC percentage quantified through FACS for different flavivirus-stimulated PBMC cultures. (B–E) Correlation between the Kyn levels and ASC numbers (counted through ELISPOT) derived from each cell culture.