Table 1.
Summary of the Function(s) of Sc Hsp31 paralogs and human DJ-1.
| Function(s) | Hsp31 | Hsp32 | Hsp33 | Hsp34 | hDJ-1 | References |
|---|---|---|---|---|---|---|
| Sequence Homology within the paralogs and hDJ-1 |
70% (16–35%) |
99.5% (16–35%) |
99.5% (16–35%) |
99.5% (16–35%) |
_ | [4,5] |
| Catalytic site residues, (Cys, His, Glu) |
Yes | Yes | Yes | Yes | Yes | [4,13,14] |
| Mutations linked to early onset of familial PD |
_ | _ | _ | _ | Yes | [15] |
| Role in protein quality control | Yes | Yes | Yes | Yes | Yes | [16,17] |
| Methylglyoxalase Activity | Yes | ND | ND | ND | Yes | [6,18] |
| Role in Oxidative Stress | Yes | Yes | Yes | Yes | Yes | [6,7,19] |
| Regulation of 20S proteasome complex |
ND | ND | ND | ND | Yes | [20] |
| Role in cell survival during Diauxic shift |
Yes | Yes | Yes | Yes | ND | [7] |
| Role in Autophagy | Yes | Yes | Yes | Yes | Yes | [7,21] |
| Localization of the protein¥ | Cytosolic | Cytosolic | Cytosolic | Cytosolic | Cytosolic/ Nuclei |
[6,22] |
| Mitochondrial Translocation* | Yes# | ND | ND | ND | Yes | [6,23] |
ND: Not Determined, ¥: Without Stress, *: During Oxidative stress, #: >50% of the total protein.