Table 3.
Analysis of risk variables for early recurrence (≤20 months) of type IV HC after curative surgery
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Early recurrence group (n = 127) | 20-month recurrence-free group (n = 126) | p value | HR (95% CI) | p value | |
| Gender | 0.407 | ||||
| Male | 83 | 76 | |||
| Female | 44 | 50 | |||
| Age | 0.203 | ||||
| < 70 | 112 | 103 | |||
| ≥ 70 | 16 | 23 | |||
| Total bilirubin (μmol/L) | 229.85 ± 189.53 | 183.23 ± 149.37 | 0.031 | 1.001 (0.999–1.003) | 0.170 |
| CA-199 (U/mL) | 0.032 | 1.750 (0.986–3.107) | 0.057 | ||
| < 200 | 45 | 61 | |||
| ≥ 200 | 83 | 65 | |||
| Albumin (g/L) | 0.941 | ||||
| ≤ 40 | 95 | 93 | |||
| > 40 | 33 | 33 | |||
| Pre-NLR | 0.144 | ||||
| < 3 | 87 | 96 | |||
| ≥ 3 | 41 | 30 | |||
| Post-NLR | 0.139 | ||||
| < 3 | 103 | 110 | |||
| ≥ 3 | 25 | 16 | |||
| NLRc | 0.446 | ||||
| Elevated | 63 | 56 | |||
| Decreased | 65 | 70 | |||
| Pre-LMR | 0.421 | ||||
| ≤ 3.67 | 34 | 28 | |||
| > 3.67 | 94 | 98 | |||
| Post-LMR | < 0.001 | 0.591 (0.266–1.312) | 0.196 | ||
| ≤ 4.10 | 94 | 61 | |||
| > 4.10 | 34 | 65 | |||
| LMRc | < 0.001 | 0.421 (0.188–0.942) | 0.035 | ||
| Elevated | 48 | 77 | |||
| Decreased | 80 | 49 | |||
| Resection margin | 0.002 | 2.133 (1.112–4.091) | 0.023 | ||
| R0 | 75 | 97 | |||
| R1 | 53 | 29 | |||
| Tumor differentiation | 0.065 | ||||
| Well | 25 | 37 | |||
| Moderate | 85 | 80 | |||
| Poor | 18 | 9 | |||
| AJCC T stage | 0.151 | ||||
| T1 | 5 | 12 | |||
| T2 | 77 | 66 | |||
| T3 | 37 | 43 | |||
| T4 | 9 | 5 | |||
| AJCC N stage | 0.001 | 2.061 (1.344–3.162) | 0.001 | ||
| N0 | 63 | 92 | |||
| N1 | 45 | 24 | |||
| N2 | 20 | 10 | |||
| AJCC stage | 0.094 | ||||
| I | 4 | 8 | |||
| II | 40 | 51 | |||
| III | 64 | 57 | |||
| IV | 20 | 10 | |||
| Portal vein invasion | 0.132 | ||||
| Positive | 28 | 38 | |||
| Negative | 100 | 88 | |||
| Hepatic artery invasion | 0.119 | ||||
| Positive | 18 | 10 | |||
| Negative | 110 | 116 | |||
| Lymphovascular invasion | < 0.001 | 2.744 (1.345–5.595) | 0.006 | ||
| Positive | 41 | 15 | |||
| Negative | 87 | 111 | |||
| Perineural invasion | 0.383 | ||||
| Positive | 86 | 91 | |||
| Negative | 42 | 35 | |||
| Tumor size (cm) | 0.021 | 1.794 (0.826–3.897) | 0.140 | ||
| ≤ 3 | 100 | 112 | |||
| > 3 | 28 | 14 | |||
| Adjuvant therapy | 0.212 | ||||
| Yes | 54 | 63 | |||
| No | 74 | 63 | |||
The Italic emphasis (originally boldfaced) in Tables 2 and 3 specified the variables that were statistically significant in the univariate and multivariate logistic regression analysis (two-tailed P values < 0.05)