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. 2020 Feb 17;9:17. doi: 10.1186/s40169-020-0269-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Correlation between T790M relative mutation purity (RMP) and osimertinib treatment outcomes. a Objective response rate (ORR) stratified by T790M RMP quartiles (P for trend = 0.002). b Progression-free survival (PFS) stratified by T790M RMP quartiles (P for trend = 0.006). c Receiver Operating Characteristic (ROC) Curve and area under ROC curve for T790M RMP predicting objective response. d ORR stratified by RMP-low and RMP-high patients (21.1% vs 65.6%, P = 0.002). e PFS stratified by RMP-low and RMP-high patients (P = 0.013, log-rank test)