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. 2020 Feb 17;10:2780. doi: 10.1038/s41598-020-59672-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of the initiation of the biochemical oil production in yeasts showing the steps within the pathway catalysed by the studied enzymes under nitrogen limitation. ACC, acetyl-CoA carboxylase, AMPD, AMP deaminase, ACS, ATP-citrate synthase, FASI & II, fatty acid synthase subunits alpha and beta and ICDH, isocitrate dehydrogenase [NADP]. × and ↑ indicates the inhibition of ICDH and increased activity of AMPD under nitrogen limitation. Modified from⁷