Table 2.

Cohort specific and meta-analyzed associations between the alcohol consumption PRS and alcohol-related (a) morbidity and (b) mortality.

	FINRISK	Health 2000	Meta-analysis
(a) Alcohol-related morbidity	Cases = 817	Cases = 171	Cases = 988
Basic model with age and sex	HR = 1.25 [1.16–1.34], p = 5.9 × 10–10	HR = 1.32 [1.13–1.53], p = 0.00036	HR = 1.26 [1.18–1.34], p = 1.1 × 10–12
Model with alcohol consumption	HR = 1.13 [1.06–1.21], p = 0.00053	HR = 1.23 [1.06–1.43], p = 0.0081	HR = 1.15 [1.08–1.22], p = 2.1 × 10–5
Fully adjusted model	HR = 1.14 [1.06–1.22], p = 0.00027	HR = 1.20 [1.03–1.4], p = 0.022	HR = 1.15 [1.08–1.22], p = 2.0 × 10–5
(b) Alcohol-related mortality	Deaths = 264	Deaths = 71	Deaths = 335
Basic model with age and sex	HR = 1.21 [1.07–1.37], p = 0.0022	HR = 1.41 [1.11-1.8], p = 0.0045	HR = 1.25 [1.12-1.4], p = 5.9 × 10–5
Model with alcohol consumption	HR = 1.08 [0.952–1.22], p = 0.24	HR = 1.34 [1.05–1.71], p = 0.017	HR = 1.13 [1.01–1.26], p = 0.033
Fully adjusted model	HR = 1.08 [0.957–1.23], p = 0.21	HR = 1.22 [0.965–1.55], p = 0.096	HR = 1.11 [0.996–1.24], p = 0.058

In the fully adjusted model, age, sex, alcohol consumption, smoking, education, marital status, and GGT (U/I) were used as non-genetic covariates