Figure 5.

On an aversive pattern separation test, mice exposed to whole body ⁵⁶Fe IRR at 6-month of age discriminate two contexts earlier than mice exposed to Sham IRR. (a) Sham mice discriminate Context A (shock context) from Context B (non-shock context) by Block 5. (b,c) Frac (b) and Non-Frac (c) ⁵⁶Fe mice discriminate Context A from Context B by Block 2. (d–f) When examined at Block 2 (d), Block 4 (e), and Block 6 (f), Frac and Non-Frac ⁵⁶Fe discriminate by Block 2. Sham: n = 10, Frac:n = 10, Non-Frac: n = 9. Mean ± SEM. Two-way RM ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, Bonferroni post-hoc tests in a–f. a p < 0.05, a’ p < 0.01, a” p < 0.001, a”’ p < 0.0001 in Context A vs B. Frac = fractionated, Non-Frac = non-fractionated.