Figure 6.

On an aversive pattern separation test, mice exposed to a different HZE particle - ²⁸Si - at 6 month of age also discriminate two contexts earlier than mice exposed to Sham IRR. (a) Sham mice discriminate Context A (shock context) from Context B (non-shock context) by Block 5. (b,c) While 20 cGy ²⁸Si mice (b) discriminate Context A from Context B by Block 5, 100 cGy ²⁸Si mice (c) discriminate by Block 3. (d–f) When examined at Block 2 (d), Block 4 (e), and Block 6 (f), 100 cGy Si mice by Block 4 and both 20 cGy and 100 cGy ²⁸Si mice discriminate by Block 6. Sham: n = 8, Frac:n = 8, Non-Frac: n = 8. Mean ± SEM. Two-way RM ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, Bonferroni post-hoc tests in a-c,e-f, #p = 0.05–0.06, a p < 0.05, a’ p < 0.01, a” p < 0.001, a”’ p < 0.0001 in Context A vs. B.