Figure 7.

Stereological quantification reveals fewer immature dentate gyrus neurons (doublecortin (DCX)+ cells) 4 months post-whole body ⁵⁶Fe particle IRR relative to Sham mice. (a) Representative photomicrograph of DCX+ cell in the mouse dentate gyrus subgranular zone. Insets: higher magnification of boxed areas in main image. Scale bar = 100 um in a, 10 um in inset ii. (b,c) Relative to Sham mice, Frac, and Non-Frac ⁵⁶Fe mice have fewer DCX + dentate gyrus cells. Sham: n = 10, Frac:n = 10, Non-Frac: n = 9. Mean ± SEM. One-way ANOVA Bonferroni posthoc. *p < 0.05 in b, Two-way ANOVA, Bonferroni posthoc. a’ p < 0.01 Sham vs. Frac, b p < 0.05, b” p < 0.001 Sham vs. Frac in c. Frac = fractionated, Non-Frac = non-fractionated.