Table 3.

Comparison of mutation frequency among the three cohorts.

Characteristics		Vietnam (N = 220)		MSK-IMPACT (N = 764)			East Asia (N = 361)
		N	%	N	%	p	N	%	p
Sex	Female	90	40.9	447	58.5	<0.00001	201	55.7	<0.001
	Male	128	58.2	317	41.5		160	44.3
	UN	2	0.9	0	0.0		0	0
Age at diagnosis	Min	31		19		<0.001	22		<0.001
	Max	86		93			84
	Median	61		64			58
EGFR	Mutant	83	37.7	222	29.1	<0.05	265	73.4	<0.00001
	WT	137	62.3	542	70.9		96	26.6
KRAS	Mutant	47	21.4	188	24.6	NS	33	9.1	<0.0001
	WT	173	78.6	576	75.4		328	90.9
NRAS	Mutant	1	0.5	10	1.3	NS	Not tested
	WT	219	99.5	754	98.7
BRAF	Mutant	5	2.3	26	3.4	NS	5	1.4	NS
	WT	215	97.7	738	96.6		356	98.6
ALK	Mutant	17	7.7	30	3.9	NS	31	10.0	NS
	WT	203	92.3	734	96.1		330	90.0
ROS1	Mutant	5	2.3	23	3.0	NS	6	1.7	NS
	WT	215	97.7	741	97.0		355	98.3

N: total case number

n: number of cases

%: percentage of cages

UN: unknown

WT: wild type

Kruskal-Wallis and Dunn’s multiple comparison test was conducted to compare the median age of patients at diagnosis

Chi-squared (χ²) test was performed to compare gender and mutation frequencies and the p-values were subsequently adjusted by Bonferroni correction.

NRAS mutations were not tested in the East Asian cohort.