Table 4.
Association between clinical factors and mutation frequencies of NSCLC driver genes.
| Clinical characteristics | Total | EGFR | KRAS | NRAS | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Not mutated | Mutated | p value | Not mutated | Mutated | p value | Not mutated | Mutated | p value | |||||||||
| Sex | Female | 131 | 68 | 51.9 | 63 | 48.1 | <0.0001 | 119 | 90.8 | 12 | 9.2 | <0.00001 | 131 | 100.0 | 0 | 0.0 | NS |
| Male | 212 | 155 | 73.1 | 57 | 26.9 | 147 | 69.3 | 65 | 30.7 | 210 | 99.1 | 2 | 0.9 | ||||
| Unknown | 7 | 3 | 42.9 | 4 | 57.1 | 5 | 71.4 | 2 | 28.6 | 7 | 100.0 | 0 | 0.0 | ||||
| Age | <=61 | 174 | 112 | 64.4 | 62 | 35.6 | NS | 139 | 79.9 | 35 | 20.1 | <0.05 | 172 | 98.9 | 2 | 1.1 | NA |
| >61 | 170 | 112 | 65.9 | 58 | 34.1 | 127 | 74.7 | 43 | 25.3 | 170 | 100.0 | 0 | 0.0 | ||||
| Unknown | 6 | 2 | 33.3 | 4 | 66.7 | 5 | 83.3 | 1 | 16.7 | 6 | 100.0 | 0 | 0.0 | ||||
|
Smoking status |
Yes | 54 | 38 | 70.4 | 16 | 29.6 | <0.01 | 38 | 70.4 | 16 | 29.6 | <0.0001 | 54 | 100.0 | 0 | 0.0 | NA |
| No | 131 | 63 | 48.1 | 68 | 51.9 | 122 | 93.1 | 9 | 6.9 | 131 | 100.0 | 0 | 0.0 | ||||
| Unknown | 165 | 53 | 32.1 | 112 | 67.9 | 93 | 56.4 | 72 | 43.6 | 163 | 98.8 | 2 | 1.2 | ||||
| Histology | ACC | 241 | 155 | 64.3 | 86 | 35.7 | <0.05 | 185 | 76.8 | 56 | 23.2 | NS | 240 | 99.6 | 1 | 0.4 | NS |
| SCC | 25 | 21 | 84 | 4 | 16 | 19 | 76 | 6 | 24 | 24 | 96 | 1 | 4 | ||||
| Unknown | 84 | 50 | 59.5 | 34 | 40.5 | 67 | 79.8 | 17 | 20.2 | 84 | 100.0 | 0 | 0.0 | ||||
| Clinical characteristic | Total | BRAF | ALK | ROS1 | |||||||||||||
| Not mutated | Mutated | p value | Not mutated | Mutated | p value | Not mutated | Mutated | p value | |||||||||
| Sex | Female | 131 | 128 | 97.7 | 3 | 2.3 | NS | 120 | 91.6 | 11 | 8.4 | NS | 124 | 94.7 | 7 | 5.3 | NS |
| Male | 212 | 207 | 97.6 | 5 | 2.4 | 201 | 94.8 | 11 | 5.2 | 208 | 98.1 | 4 | 1.9 | ||||
| Unknown | 7 | 7 | 100.0 | 0 | 0.0 | 6 | 85.7 | 1 | 14.3 | 7 | 100.0 | 0 | 0.0 | ||||
| Age | <=61 | 174 | 171 | 98.3 | 3 | 1.7 | NS | 157 | 90.2 | 17 | 9.8 | <0.05 | 165 | 94.8 | 9 | 5.2 | <0.05 |
| >61 | 170 | 165 | 97.1 | 5 | 2.9 | 164 | 96.5 | 6 | 3.5 | 168 | 98.8 | 2 | 1.2 | ||||
| Unknown | 6 | 6 | 100.0 | 0 | 0.0 | 6 | 100.0 | 0 | 0.0 | 6 | 100.0 | 0 | 0.0 | ||||
| Smoking status | Yes | 54 | 54 | 100.0 | 0 | 0.0 | NA | 53 | 98.1 | 1 | 1.9 | NS | 54 | 100.0 | 0 | 0.0 | NA |
| No | 131 | 127 | 96.9 | 4 | 3.1 | 122 | 93.1 | 9 | 6.9 | 131 | 100.0 | 0 | 0.0 | ||||
| Unknown | 165 | 159 | 96.4 | 6 | 3.6 | 144 | 87.3 | 21 | 12.7 | 154 | 93.3 | 11 | 6.7 | ||||
| Histology | ACC | 241 | 235 | 97.5 | 6 | 2.5 | NS | 223 | 92.5 | 18 | 7.5 | NA | 236 | 97.9 | 5 | 2.1 | NS |
| SCC | 25 | 24 | 96 | 1 | 4 | 25 | 100 | 0 | 0 | 24 | 96 | 1 | 4 | ||||
| Unknown | 84 | 83 | 98.8 | 1 | 1.2 | 79 | 94.0 | 5 | 6.0 | 79 | 94.0 | 5 | 6.0 | ||||
N: total case number
n: number of particular group
%: percentage of particular cases in total number cases
Chi squared (χ²) test (sample size >5) or Fisher’s exact test (sample size< = 5) was performed to estimate p value.
AC: adenocarcinoma; SCC: squamous carcinoma; UN: unknown;