Table 2.
Baseline values and changes in biomarkers for intestinal inflammation and permeability, liver function and Vitamin B12 levels throughout the study; data are given as mean (95% confidence interval), [aall patients, bselected patients with increased baseline values].
| Before Intervention | After Intervention | Follow up | p-value (Before vs. After) | p-value (Before Intervention vs. Follow-up) | |
|---|---|---|---|---|---|
| Calprotectin (ng/mg)a | 147.1 (106.4;187.8) | 128.3 (92.1; 164.5) | 142.9 (107.3; 178.4) | 0.192 | — |
| - when >50 ng/mg at baselineb | 168.7 (123.7; 213.7) | 142.6 (101.0; 184.2) | 161.5 (122.1; 200.9) | 0.090 | — |
| Zonulin (ng/mg)a | 60.9 (44.4; 77.5) | 51.2 (41.8; 60.6) | 51.9 (40.0; 63.8) | 0.385 | — |
| - when >50 ng/mg at baselineb | 100.1 (73.8; 126.4) | 53.8 (41.5; 66.0) | 48.7 (33.7; 63.8) | <0.001 | 0.007 |
| Lipopolysaccharide (EU/ml) | 1.9 (0.9; 2.9) | 1.6 (0.9; 2.3) | 2.3 (1.2; 3.4) | 0.428 | — |
| Lipopolysaccharide-binding protein (ng/ml) | 14.8 (12.3; 17.2) | 14.6 (12.8; 16.4) | 12.9 (10.9; 15.0) | 0.561 | — |
| sCD14 (µg/ml) | 2.3 (2.1; 2.6) | 2.5 (2.2; 2.8) | 2.1 (1.9; 2.2) | 0.177 | — |
| Albumin (g/dl) | 4.1 (4.0; 4.2) | 4.2 (4.1; 4.3) | 4.2 (4.1; 4.4) | 0.027 | 0.013 |
| Alanine aminotransferase (U/l) | 29.3 (24.2; 34.3) | 27.8 (23.4; 32.1) | 25.5 (22.4; 28.7) | 0.317 | — |
| Aspartate transaminase (U/l) | 32.0 (27.9; 36.1) | 29.1 (25.2; 33.1) | 28.1 (23.9; 32.3) | 0.016 | 0.005 |
| Alkaline Phosphatase (U/l) | 76.1 (67.0; 85.1) | 79.9 (70.9; 89.0) | 79.6 (69.5; 89.7) | 0.004 | 0.006 |
| Thrombocytes (G/l) | 196 (163; 229) | 207 (174; 240) | 216 (185; 247) | 0.010 | 0.138 |
| PZINR | 1.1 (1.0; 1.2) | 1.1 (1.0; 1.2) | 1.0 (0.9; 1.1) | 0.695 | — |
| Vitamin B12 (ng/l) | 406 (355; 457) | 416 (362; 469) | 445 (382; 508) | 0.784 | — |
| C-reactive proteins (mg/l) | 3.4 (2.0; 4.9) | 3.0 (2.1; 3.9) | 3.8 (2.2; 5.5) | 0.388 | — |