Table 1.

Main clinical-demographic characteristics of the training sample (n = 847) and testing sample (n = 362).

Variable	Training sample (n = 847)	Testing sample (n = 362)
Age	51.44 ± 13.94	51.87 ± 14.16
Gender (F/M)	566/281	235/127
Phenotype of interest	TRD n = 353 Non-Responders n = 291 Responders = 203	TRD = 151 Non-responders n = 125 Responders = 86
Baseline MADRS score	34.56 ± 7.36	33.85 ± 7.69
Current MADRS score	24.73 ± 11.13	24.78 ± 11.60
Treatment	Serotonergic n = 421 Noradrenergic n = 271 Serotonergic–noradrenergic n = 128 Other n = 27	Serotonergic n = 192 Noradrenergic n = 93 Serotonergic–noradrenergic n = 59 Other n = 18

The baseline MADRS score is referred to the beginning of the current depressive episode. Mean ± standard deviation is reported for continuous variables and distribution for dichotomous ones. For a more comprehensive overview of patients’ characteristics and results of comparisons between the characteristics of the two subsamples see Supplementary Table 1.

MADRS Montgomery and Åsberg Depression Rating Scale; TRD treatment-resistant depression.