Table 3.

best predictive models of treatment-resistant depression (TRD) vs. response in the replication samples.

Sample	Genetic predictors	Genetic predictors AUC (95% CI)	Clinical and genetic predictors AUC (95% CI)
GENDEP, whole sample (n = 321)	Pathways, rare variants	0.54 (0.47–0.60)	0.60 (0.54–0.65)
GENDEP, 5-HT antidepressants (n = 188)	Genes, rare and common variants	0.58 (0.49–0.68)	0.62 (0.53–0.72)
STAR*D, whole sample (n = 807)	Genes, rare and common variants	0.51 (0.46–0.55)	0.55 (0.51–0.59)
STAR*D, 5-HT antidepressants, ≤20 or ≥80 percentiles (n = 266)	Pathways, rare variants	0.59 (0.48–0.69)	0.61 (0.51–0.71)
STAR*D, 5-HT antidepressants, ≤10 or ≥90 percentiles (n = 134)	Pathways, rare variants	0.73 (0.61–0.86)	0.72 (0.58–0.86)

For a detailed overview of all results in the replication samples see Supplementary Table 12. In STAR*D, more extreme percentiles of the genetic predictors were considered compared to other samples because of the larger sample size (for details see the section “Replication in STAR*D and GENDEP”). 5-HT antidepressants = serotonergic antidepressants, Cl confidence intervals.