Table 3.
Effects of SRS intervention time on CRN based on TKI therapy.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | |
| Age | 0.986 | 0.959–1.014 | 0.313 | 0.970 | 0.940–1.001 | 0.057 |
| Gender | 0.839 | 0.815 | ||||
| Male | 1.000 | 1.000 | ||||
| Female | 0.938 | 0.506–1.739 | 0.925 | 0.480–1.782 | ||
| Treatment volume | 0.999 | 0.995–1.002 | 0.389 | 0.997 | 0.993–1.001 | 0.184 |
| Fraction | 1.075 | 0.801–1.441 | 0.631 | 1.415 | 0.962–2.081 | 0.078 |
| Radiation dose | 1.021 | 0.993–1.049 | 0.146 | 1.023 | 0.992–1.055 | 0.156 |
| SRS | 0.001 | 0.001 | ||||
| Before TKI resistance | 1.000 | 1.000 | ||||
| After TKI resistance | 3.162 | 1.587–6.299 | 3.551 | 1.710–7.377 | ||
SRS, stereotactic radiosurgery; CRN, cerebral radiation necrosis; TKI, tyrosine kinase inhibitor.