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. 2020 Feb 11;11:58. doi: 10.3389/fphys.2020.00058

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Copyright © 2020 Kumar, Jin, Watts and Rockwell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PVATs were mostly similar in numbers of CD8 T cell subtypes vs. their respective non-PVAT fats. Immunophenotyping of mesenteric resistance (MR)PVAT, thoracic aortic (A)PVAT, retroperitoneal (RP) fat, subscapular (SS) fat, and spleen, in healthy male and female SD rats. CD8 T cell subtypes (CD8+CD25+, CD8+OX40+, CD8+Foxp3+, CD8+CD45RC–, and CD8+CD45RC+ cells) were quantified by flow cytometry. Each immune cell type is presented as absolute cell counts normalized to tissue weight (in mg). Comparisons between (A) MRPVAT and APVAT along with spleen. MRPVAT had a greater density of naive CD8 T cells vs. APVAT in females (B) MRPVAT and non-PVAT white RP fat (C) APVAT and non-PVAT brown SS fat. Bars represent means ± SEM for the number of animals indicated by N. A P < 0.05 by two-way ANOVA was considered statistically significant. * inside the stack in the graph represents a significant difference in the specific stack of immune cells between the two fats within each sex.